A 50-year-old woman with end-stage renal disease (ESRD) is diagnosed with pulmonary tuberculosis. Which of the following medications requires dose adjustment in this patient?

Explanation

Among the first-line anti-tubercular drugs, ethambutol is primarily excreted through the kidneys and therefore necessitates dose reduction in patients with impaired renal function such as those with ESRD. Rifampin, isoniazid, and pyrazinamide generally do not require dose adjustment in renal failure.