Alkaptonuria, a hereditary disorder affecting tyrosine metabolism, results from a deficiency of which enzyme?

Explanation

Alkaptonuria is caused by a lack of homogentisate oxidase (also known as homogentisate dioxygenase), an enzyme involved in the breakdown of tyrosine. Deficiency of this enzyme leads to accumulation of homogentisic acid, resulting in the disease. Other enzymes listed are not responsible for this condition.