During the TCA cycle, at which step does substrate-level phosphorylation occur?

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Conversion of alpha-ketoglutarate to succinyl CoATransformation of succinyl CoA into succinateOxidation of succinate to fumarateCondensation of oxaloacetate with acetyl-CoA to form citrateIsomerization of citrate to isocitrate

Explanation

Substrate-level phosphorylation in the TCA cycle happens specifically during the conversion of succinyl CoA to succinate, where a high-energy thioester bond is used to generate GTP (or ATP). Other steps involve oxidation or rearrangement but do not produce ATP directly.