In sickle cell anemia, which amino acid substitution occurs in the beta-globin chain?

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Valine replaces glutamic acid at the sixth position of the beta chainPhenylalanine substitutes glutamic acidTyrosine replaces valine at the sixth position of the beta chainAll of the above

Explanation

The mutation causing sickle cell anemia involves the replacement of glutamic acid by valine at the sixth position of the beta-globin chain. Other substitutions listed are incorrect.