What is the effect of administering penicillin G together with probenecid?

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Enhanced elimination of probenecid through feces and sweatElevated urinary clearance of probenecidAccelerated breakdown of penicillin GReduced kidney clearance of penicillin G

Explanation

When penicillin G is given with probenecid, the renal excretion of penicillin G is decreased. Probenecid inhibits the tubular secretion of penicillin, leading to higher blood levels and prolonged action of the antibiotic.