What is the primary mechanism by which bacteria develop resistance to tetracycline?

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Modification of the sites where the drug bindsChanges in the enzyme dehydrofolate reductaseEnzymatic destruction or inactivation of the antibioticReduced absorption of the drug into bacterial cells

Explanation

Bacterial resistance to tetracycline mainly occurs through enzymatic inactivation of the antibiotic, which prevents it from exerting its effect. Other mechanisms, such as modification of binding sites or decreased drug uptake, are less commonly involved in tetracycline resistance.