Which agent is used to manage severe bleeding caused by an overdose of heparin?

Explanation

Protamine sulfate is the antidote that neutralizes the anticoagulant effects of heparin, effectively controlling bleeding caused by heparin overdose. Vitamin K is used to reverse warfarin effects, factor VIII is involved in hemophilia treatment, and EACA is an antifibrinolytic agent not used for heparin reversal.