Which enzyme primarily facilitates the activation of xenobiotics during the detoxification process?

Explanation

Cytochrome P-450 is the key enzyme involved in the metabolic activation of xenobiotics, initiating their transformation during detoxification. Other enzymes like Glutathione S-transferase, NADPH cytochrome P-450 reductase, and Glucuronyl transferase play roles in subsequent phases of metabolism but are not primarily responsible for the initial activation step.