Which medication is known to cause gynecomastia, excessive hair growth, and menstrual irregularities when used over an extended period?

Explanation

Among the listed drugs, spironolactone is associated with side effects such as gynecomastia, hirsutism, and menstrual disturbances during long-term therapy. Other options like hydrochlorothiazide, amiloride, and acetazolamide do not typically produce these hormonal side effects.