Which medication is proven to help prevent gastric aspiration syndrome in patients exhibiting reflux symptoms?

Explanation

Metoclopramide is effective in reducing the risk of gastric aspiration syndrome by enhancing gastric emptying and increasing lower esophageal sphincter tone, which helps prevent reflux. Ondansetron is primarily an antiemetic, sodium bicarbonate neutralizes gastric acid but does not prevent aspiration, atropine reduces secretions but is not effective for aspiration prevention, and ranitidine reduces acid production but does not protect against aspiration.