Which molecule is a potent activator of the enzyme phosphofructokinase-1?

Explanation

Phosphofructokinase-1 (PFK-1) is a key regulatory enzyme in glycolysis and is strongly stimulated by fructose 2,6-bisphosphate. This molecule acts as an allosteric activator, enhancing the enzyme's affinity for its substrates. In contrast, cyclic AMP, ATP, and citrate generally inhibit or do not activate PFK-1.