Which of the following effects is NOT observed in a patient taking 300 mg of aspirin?

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Permanent blockade of the cyclooxygenase enzymeExtended duration of bleedingSuppression of thromboxane TXA2 productionReduction in prostaglandin PGI2 synthesisDecreased platelet aggregation

Explanation

At a dose of 300 mg, aspirin does not cause permanent inhibition of the cyclooxygenase enzyme. However, it leads to prolonged bleeding time, inhibits thromboxane TXA2, and reduces prostaglandin PGI2 levels.