Which of the following factors does NOT influence allergic reactions?

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Prior exposure to the medicationAmount of the drug administeredThe drug's pharmacological effectsInteraction between antigen and antibodyImmune system sensitivity

Explanation

Allergic reactions are dependent on previous exposure to the drug, the pharmacological properties of the drug, and the antigen-antibody response. However, the dosage of the drug does not directly affect the occurrence of allergic reactions.