Which of the following is NOT a characteristic feature of granuloma?

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A distinct form of long-term inflammationBuild-up of altered macrophage cellsTriggered by various infectious and non-infectious causesAn acute inflammatory responseFormation of multinucleated giant cells

Explanation

Granulomas represent a specialized type of chronic inflammation involving the aggregation of modified macrophages and are commonly triggered by diverse infectious and non-infectious factors. They are not associated with acute inflammatory reactions.