Which of the following is NOT a systemic effect caused by corticosteroids?

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Elevation of IL-1 levelsRise in circulating neutrophil countEnhanced anti-inflammatory responseSuppression of phospholipase A2 activity

Explanation

Corticosteroids typically reduce IL-1 levels rather than increase them. They do increase the number of circulating neutrophils, boost anti-inflammatory effects, and inhibit phospholipase A2. Therefore, an increase in IL-1 is not a systemic effect of corticosteroids.