Which of the following side effects of penicillin is dependent on the dosage administered?

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Rash on the skinInflammation of the kidney's interstitial tissueFever caused by the drugBrain dysfunction (encephalopathy)

Explanation

Among the listed adverse effects, encephalopathy is known to be dose-related with penicillin use, whereas skin rash, interstitial nephritis, and drug fever are not typically dependent on the dose.