Which of the following statements is NOT true regarding the common characteristics of a periapical granuloma?

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It is composed of actively growing granulation tissue.Its development requires resorption of the surrounding periapical bone.There is no indication of antibody production occurring locally within the lesion.It arises due to tissue injury caused by immune system responses.It is typically associated with chronic inflammation at the tooth apex.

Explanation

Periapical granulomas are made up of proliferating granulation tissue (A) and develop only after the periapical bone has been resorbed (B). They result from immunologically driven tissue damage (D). However, local antibody production is not a characteristic feature of periapical granulomas, making option C incorrect.