Which type of cells does the HIV envelope glycoprotein gp120 specifically attach to?

Explanation

The gp120 glycoprotein on the HIV envelope binds specifically to CD4 receptors, which are found on CD4-positive T lymphocytes. This interaction is crucial for viral entry into the host cells. Other immune cells like CD8 T-cells, B cells, and NK cells do not express CD4 and therefore are not the primary targets for gp120 binding.