Which virus is most commonly associated with crossing the placenta and causing congenital abnormalities in the fetus?

Explanation

Among the listed viruses, Rubella is well-known for its ability to cross the placental barrier during pregnancy, leading to congenital defects in the developing fetus. Herpes Simplex and Mumps viruses do not typically cause such placental transmission, and Papillomavirus is not associated with fetal abnormalities.